Differential expression of GPR15 on T cells during ulcerative colitis

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Differential expression of GPR15 on T cells during ulcerative colitis.

G protein-coupled receptor 15 (GPR15) was recently highlighted as a colon-homing receptor for murine and human CD4+ T cells. The aim of this study was to explore the functional phenotype of human GPR15+CD4+ T cells, focusing on Tregs and effector T cells (Teffs), and to determine whether GPR15 is the driver for the migration of T cells to the colon during ulcerative colitis (UC). In the periphe...

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ژورنال

عنوان ژورنال: JCI Insight

سال: 2017

ISSN: 2379-3708

DOI: 10.1172/jci.insight.90585